| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac288e3421d9aa90f6344fc3d8c24e6c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138 |
| filingDate |
2007-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2eb3b29c1d7bd2874ad6dea1bc8f0e74 |
| publicationDate |
2008-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008048194-A1 |
| titleOfInvention |
Use of the protein kinase c inhibitor tamoxifen for the treatment of bipolar disorder |
| abstract |
Bipolar subjects with manic/mixed episode were randomly assigned to receive either tamoxifen (80mg/day) or identical placebo tablets in 1:1 ratio for three weeks. At the end of three weeks of trial tamoxifen treatment has been shown to have strong anti-manic properties. Protein kinase C inhibition seems to be one of the direct targets of lithium and valproate, The existing effective treatments in bipolar disorder/mania. These findings may lead to delineation of the underlying pathophysiology of bipolar disorder and development of novel therapeutics. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10376479-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021205404-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9333190-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010135703-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012201908-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012527484-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021205405-A1 |
| priorityDate |
2006-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |