abstract |
The invention relates to a new improved process to prepare amorphous form of [2S-(3R*, 4aR*, 8aR*, 2'S*, 3'S*)]-2'-[2'-hydroxy-3'-phenylthiomethyl-4'-aza-5'-(2'methyl-3'-hydroxyphenyl)pentyl]decahydroisoquinoline-3-N-tert-butylcarboxamide methanesulfonate of the following Formula (I). |