| abstract |
A pharmaceutical composition and method is provided for modulating an immune response in a warm-blooded vertebrate animal. The method comprises administering to the animal an immunomodulatory composition comprising an anthelmintic benzimidazole compound. More particularly, in one embodiment the animal to be treated is afflicted with a disease state selected from the group consisting of a non-parasitic infection, an autoimmune disorder, an inflammatory disorder, an immunodeficiency-related disorder, and neoplasia. In one embodiment the anthelmintic benzimidazole compound is selected from the group consisting of fenbendazole, thiabendazole, mebendazole, and albendazole. In one embodiment a method of enhancing a vaccine's efficacy is provided wherein a vaccine composition and an anthelmintic benzimidazole compound are co-administered to a warm-blooded vertebrate animal. |