| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a556b1909f3036a88b1273c91cf6835b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55e228aa24e0e96df2253e5191656d5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6e4a54a61ccf2f9cb4d46d5160eafe6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f5848bed88ce27cfa0a7cab7d4851b5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-569 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| filingDate |
2007-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36b97873709b835f2d8f920a71ca4ce5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35e2dbc521683657650bad4712544fd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41e3d903252bf96f4d945490d7d435c0 |
| publicationDate |
2008-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008035216-A9 |
| titleOfInvention |
Generation of heavy-chain only antibodies in transgenic animals |
| abstract |
The present invention relates to methods for engineering VH domains to improve their solubility and stability. The invention provides for the incorporation of defined amino acid substitutions based on 3-D structural information into the V segments of a heavy chain locus, expressing the locus in a non-human mammal and selecting soluble VH domains. Further stabilising or solubilising mutations maybe introduced as a result affinity maturation during B-cell maturation in vivo. |
| priorityDate |
2006-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |