http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008032039-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49431a7aa8f5a27557fb8638a9e97b63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1762b82a847a36c734129e40484ac6ae |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23J3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23J3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23J3-16 |
| filingDate | 2007-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063bc433c6dc512c724a1870e8be6e45 |
| publicationDate | 2008-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2008032039-A2 |
| titleOfInvention | Denaturation control |
| abstract | The invention provides a method for monitoring the degree of protein denaturation and aggregation during the course of a heat treatment process comprising the steps of : heating an aqueous protein-containing fluid to a temperature corresponding to a heat treatment intensity in proximity to a previously established expected heat treatment intensity; collecting a sample of the heated protein solution; diluting said sample (s) in a buffer formulated so that: the pH in said sample is substantially unchanged, the ionic conditions in said sample are substantially unchanged, and the viscosity of said sample is at least substantially- maintained, all relative to the undiluted sample, measuring the turbidity of said sample relative to an untreated control sample; comparing the turbidity measurement obtained with previously established turbidity measurement limits corresponding to a desired average protein aggregate size range; collecting a sample of the heated protein solution; mixing said sample (s) with a chemical -SH group reaction measurement system; and comparing the SH-group measurement obtained with previously established SH-group measurement limits corresponding to a desired degree of denaturation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013130965-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2429305-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-6995827-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104619200-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3484304-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013132265-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018011392-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019521687-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9247767-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109843072-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11252977-B2 |
| priorityDate | 2006-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.