| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10eaabfc54247e6c9790995bf346b0e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_83d186ea3a6741bc8d7f410c99a8f2f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f207789651cdf8a6391d337fed9ff017 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-015
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-015 |
| filingDate |
2007-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_869e9d31800996259ae981f41cff7355
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_074ed851fd2e8c2ad5035eed51e754b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7cbfa9d7cb352006824a47d97a3ccd2 |
| publicationDate |
2008-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008024374-A2 |
| titleOfInvention |
Inhibitors of pancreatic phospholipase a2 for altering cholesterol and fat uptake |
| abstract |
Disclosed herein are methods for regulation of fat and/or cholesterol uptake from the gastrointestinal tract and/or regulation of plasma fat and/or cholesterol levels comprising administering to a mammal in need thereof an effective amount of a regulator of pancreatic IB PLA2 functionality. Also disclosed herein are methods of regulating the function of a polypeptide of interest comprising inserting of the 62-66 loop region of a pancreatic IB PLA2 amino acid sequence into the polypeptide of interest; and administering an effective amount of a regulatory molecule that effects its regulation through said amino acid sequence. Further disclosed are novel bile salt compounds that regulate pancreatic IB PLA2. Methods for detecting altered pancreatic IB PLA2 function and methods for identifying an agent suitable for regulating pancreatic IB PLA2 enzyme functionality are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10561670-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9770456-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9271949-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10159680-B2 |
| priorityDate |
2006-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |