| abstract |
The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (w), (y), (z1) or (z2): and wherein: Q1 is NH or NMe, in which case Q2 is -C(O)-, -S(O)2-, -C(O)NH- or -C(O)NMe-; or Q1 is a bond or -0-, in which case Q2 is a bond; or Q1 is -C(O)-, in which case Q2 is NH or NMe; or Q1 is -S(O)2-, in which case Q2 is NH, NMe or a bond; and Q3 is a bond, NH or NMe; and L is (CH2)n wherein n is 4 to 13; or L is -(CH2)m1-O-(CH2)m2-. The invention also provides the use of the compounds as inhibitors of phosphodiesterase type IV (PDE4) e.g. for the treatment and/or prophylaxis of chronic obstructive pulmonary disease (COPD), asthma, or rhinitis. |