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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_edc84e4b75a26ca33c0dc36dd165d835
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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-575
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5017
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
filingDate 2007-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c82175ec69a01674744959aa79d8b1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_817fb833419e804d23abb9507c610f52
publicationDate 2008-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2008011437-A1
titleOfInvention Gamma secretase notch biomarkers
abstract The present invention relates to the biomarker TFF-3 that measures y-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by -secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical, clinical, and/or post-clinical testing. The reagents and methods of the invention can be used to identify and maintain preferred doses of test compounds and thereby prevent medical complications, such as gastrointestinal cellular damage.
priorityDate 2006-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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