| abstract |
[PROBLEMS] To provide a compound which can act as an NMDA antagonist having a wide safe range and is useful as a therapeutic agent or a prophylactic agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic stroke or a pain. [MEANS FOR SOLVING PROBLEMS] A novel compound characterized by having an amino group and a group R1 [which represents a lower alkyl, a cycloalkyl, -lower alkylene-aryl, an aryl which may have a substituent or the like] on a carbon atom in an indan, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine or cyclopenta[c]pyridine ring or a 2,3-dihyro-1-benzofuran, 2,3-dihydro-1-benzothiophene or indolin ring or the like and also having groups R2 and R3 [which independently represent a lower alkyl or an aryl] on a carbon atom adjacent to the above-mentioned carbon atom, or a salt thereof; and an NMDA antagonist comprising the compound or the salt as an active ingredient. |