| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2210ae9270f9e8f7d16a7964cd4cbd04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6d6b3c3cc1b7352ba70408d5b5318941
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa8f4341ac61b871859158fe69633523 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6891
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 |
| filingDate |
2007-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb83870a817365e4f882f7b3b30e8880
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3a861e9714239c9f6bc5caf357a28a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aba8111e169e3a5a1eafcb01358d0eca |
| publicationDate |
2008-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2008006102-A2 |
| titleOfInvention |
Use of retro-aldol reaction to generate reactive vinyl ketone for attachment to anitibody molecules by michael addition reaction for use in immunostaining and immunotargeting |
| abstract |
The present invention is directed to methods for formation of a chemically programmed antibody comprising the steps of: (1) reacting a conjugate comprising a signal module covalently linked to a proadapter with a catalytic moiety selected from the group consisting of a catalytic antibody and a Fab fragment of a catalytic antibody, wherein the proadapter includes therein a precursor to a reactive moiety activated to a reactive moiety by a reaction catalyzed by the catalytic moiety; and (2) crosslinking the reactive moiety to a side chain of an amino acid residue in the active site of the catalytic moiety to produce the chemically programmed antibody. The invention also encompasses chemically programmed antibodies formed by these methods, methods for their use, and pharmaceutical compositions, as well as proadaptors and conjugates including them. Chemically programmed antibodies are useful for the treatment of cancer, particularly in metastasis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9132188-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010093706-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8518927-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9173953-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011012722-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021501754-A |
| priorityDate |
2006-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |