| abstract |
Surprisingly, the present inventors have discovered that expression of TAT- 048 protein in human patients is associated with cancer, and that the over-expressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-048 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-048 expression or activity, comprising: contacting a candidate compound with a TAT-048 and detecting the presence or absence of binding between said compound and said TAT-048, or detecting a change in TAT-048 expression or activity. Methods are also included for the identification of compounds that modulate TAT-048 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-048 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds. |