| abstract |
The present invention provides a method for the isolation of mycophenolic acid from a fermentation broth comprising the steps of: (a) Adding a water-immiscible solvent to said fermentation broth; (b) Separating the water-immiscible phase from the aqueous phase, and; (c) Adding an amine to the water-immiscible phase obtained in step (b). Furthermore, the present invention provides the use of mycophenolate amines in the preparation of mycophenolate esters, in particular mycophenolate mofetil, and mycophenolate salts, in particular mycophenolate sodium salt. |