| abstract |
The present invention relates to pharmaceutical compositions that contain two active principles, one of these being a non-steriodal anti-inflammatory analgesic known as ketorolac, or one of the pharmaceutically acceptable salts thereof, and the other being a non-steroidal anti-inflammatory analgesic known as lysine clonixinate. When the two drugs are combined in specific proportions, the combination produces analgesic pharmacological effects that indicate superadditivity (synergy) and therefore it is possible to use a smaller quantity of the two drugs in order to achieve the same level of analgesia than when they are used alone. When the amount of each drug in the combination is reduced, the collateral effects associated with each drug are reduced in number and in degree, and therefore this therapeutic strategy may be a promising tool in the relief of moderate to severe acute pain, with the advantage of there being fewer adverse effects. |