| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_246d190198df7d6e85a868f7431abe00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47aefa977b104644df040dd15230e8f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b06be493cefc571e09cfca2736b5270
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9a36328274867f46f8fc1fb9c868703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d3d5429d3a2b38800c9c4bfeb82e776
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a10665dfaa24d32c910d828d7df292c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e10c05a7bef478d7e4253a31a6264c49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b865ba5674b59f6eab707850316350d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate |
2007-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bad463386322b550f45b09b41fba168
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a327acc1ddf380602871787728b3bf4d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9adc1b735fadb2ee33873e63228b9b75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ecd36124eea65196c5c0c5f321571a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d36bd19ac361e540db835e74f69f6a01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_188179ea5aabab846ef84649ea0d859e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_013c252253c13e0e6b73fe303e8e3dee |
| publicationDate |
2007-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007148141-A1 |
| titleOfInvention |
Process for the synthesis of benzylidene rosiglitazone base |
| abstract |
Process for the synthesis of 5-{4-[N-methyl-N- (2-pyridyl)-amino-ethoxy]- 5 benzylidene}-thiazolidine-2, 4-dione (INN name: benzylidene-rosiglitazone) of formula (I), which consist of the following steps: (I) Step a) reaction of 2-chloro-pyridine and 2-(N-methylamino)-ethanol Step b) reaction of the obtained compound of formula (III) with 4- 0 fluorobenzaldehyde Step c) reaction of the obtained compound of formula (IV) with thiazolidine-2, 4-dione. (III), ((IV). characterized by - dissolving 4-{2-[N-methyl-N- (2-pyridyl) amino]-ethanol of formula (III) obtained in Step a) in toluene and using it in Step b) without isolation; - reacting the solution of compound of formula (III) in toluene in Step b) with 4-fluorobenzaldehyde in the presence of aqueous alkali hydroxide solution and phase transfer catalyst at 25-50 °C; - reacting the solution of the benzaldehyde derivative of formula (IV) obtained in Step b) in toluene in Step c) and isolating the desired product. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112047936-A |
| priorityDate |
2006-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |