| abstract |
Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically accepted salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which R1 is selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A selected from bond, or substituted or unsubstituted hydrocarbon radical;R2, R3 each other independently is selected from hydrogen or methyl, which linked with the any position of spiro structure; n and m are integer of 0~2, and do not represent 0 at same time; B, D each other independently is lineared or branched alkylene; Y is selected from –CHR4-, O, S, -S(O)-, -SO2-, -NR4 or substituted or unsubstituted phenylene, in which R4 selected from H, saturated or unsaturated C1-C6-alkyl, substituted or unsubstituted aryl, or heteroaryl substituted methyl or ethyl; X- is pharmaceutically accepted inorganic or organic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction. |