http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007146802-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c8cbbf2290b3f3a9988da29598baa2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4babb6aa2906211b34c7cfeea70d70b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfc99a06561ce11231cb09f910c480e7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70 |
| filingDate | 2007-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53e0966fc8da5c99837ebb265c978c2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17e49941c45cf419dd7987ea0889280e |
| publicationDate | 2007-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2007146802-A2 |
| titleOfInvention | System and compositions for isolating suppressors of hiv-1 protease |
| abstract | The present invention relates to a yeast screening assay for the identification of suppressors of a protease, such as the HIV-I protease and/or HIV-2 protease, for example. Upon overexpression of HIV-I protease in Schizosaccharomyces pombe, for example, the cell dies, but in the presence of a candidate inhibitor with protease suppressor activity, the cell lives, thereby providing an assay for the identification of one or more suppressors. In additional aspects, there is an in vivo protease activity screen, used alternatively or additionally to a viability screen, such as for cleavage of a HIV-I protease-specific site. In further aspects, the suppressor is employed for the treatment of an individual infected with HIV virus or with AIDS. |
| priorityDate | 2006-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1700.