| abstract |
The present invention provides novel pyrrole derivatives represented by formula (I): wherein R1 represents a hydrogen atom, cyano, optionally halogenated C1-6 alkyl or an optionally substituted C1-6 alkoxy-carbonyl; R2 and R4 may be the same or different and represent a hydrogen atom, C1-6 alkyl, C2-6 alkenyl substituted with an optionally substituted hydroxy, an optionally substituted or oxidized thiol, etc.; R3 represents an optionally substituted thiazolyl, an optionally substituted pyrazolyl, an optionally substituted oxazolyl, etc.; and R5 represents an optionally substituted phenyl having a cyano at the 4- or 3-position, and androgen receptor antagonists containing the same. |