| abstract |
It is intended to provide a novel glycopeptide antibiotic derivative. A compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. In the formula (I), RA represents -X1-Ar1-X2-Y-X3-Ar2 (X1, X2, X3 represent a single bond, a heteroatom group selected from -N=, =N-, -NR1- (R1 represents H or lower alkyl), -O-, -S-, -SO-, and -SO2- or a linking group thereof, or alkylene or alkenylene which may be interrupted or substituted by one or more of such heteroatom groups; Y represents -NR2CO-, -CONR2- (R2 represents H or lower alkyl) or a group represented by the formula (II) (R3 represents alkylene); Ar1 and Ar2 represent a carbocyclic group or heterocyclic group which may be substituted and have an unsaturated bond; RB represents -NHNRXRY or -NRZORW (RX represents hydrogen or lower alkyl, RY represents hydrogen or lower alkyl which may be substituted, C(=NH)NH2, CSNH2, COCONH2, CN, a heterocyclic group which may be substituted or carbamoyl which may be substituted; RZ represents hydrogen or lower alkyl; RW represents hydrogen, lower alkyl which may be substituted, lower alkenyl which may be substituted, a heterocyclic group which may be substituted, heterocyclic carbonyl which may be substituted or carbamoyl which may be substituted); RC represents hydrogen or alkyl which may be substituted (the alkyl may be interrupted by a heteroatom group selected from N=, =N-, -NR1- (R1 represents H or lower alkyl), -O-, -S-, -SO-, and -SO2-); R represents alkyl which may be substituted. |