http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007138613-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f6f16ffefe8a27d92a683bdb4b43722 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2085395dc9fb0b3bae47ef08733692a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec6be4480ebfd05aab3f35dc139b633b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94e49fbad7d37b159468b9c7190721af http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a392c8007c304cfaabcdb4cec10d1ca7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-11 |
| filingDate | 2007-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c35ef1102a81bbc9dc2f9a1849955e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b3ebffc1bcac8413cfad79671f2d77d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c764d700d351b166ab923003c1ccf655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cc481b0207999e1ec3ade34de24006e |
| publicationDate | 2009-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2007138613-A3 |
| titleOfInvention | A process for synthesis of [6,7-bis-(2-methoxyethoxy)-quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride |
| abstract | The present invention provides a process for synthesizing [6,7-bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride (Erlitinib Hydrochloride) having the formula (I) comprising reacting 3,4-dihydroxy benzaldehyde with bromo derivative of ethyl methyl ether to obtain 3,4-bis(2-methoxyethoxy)benzaldehyde having formula (III). This is converted to give 3,4- bis (2-methoxyethoxy)-benzonitrile which on furthur nitration we obtain 4,5- bis (2-methoxyethoxy)-2-nitrobenzonitrile which on nitro reduction we get 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile. Formylation of this compound yields N'-[2-cyano-4,5-bis(2methoxyethoxy)phenyl]-N,N-dimethylformamidine. Coupling of this formamidine with 3-ethynyl aniline gives erlotinib free base. On furthur treatment of this free base with methanolic/ethanolic hydrochloric acid gives us erlotinib hydrochloride. |
| priorityDate | 2006-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.