| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7be8c44f8d5e305a799b1a30c192b076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_909ba0810e19731172217d39936638fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-455
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N23-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N23-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N23-207 |
| filingDate |
2007-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_626093e4d1b59cb99e721c431b7ac10a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c68585046e25a55936e25370bb5983b6 |
| publicationDate |
2007-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007136744-A1 |
| titleOfInvention |
Crystal structure of a substrate complex of nampt/pbef/visfatin |
| abstract |
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirTl activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism. The structure also reveals the basis of substrate specificity and suggests routes for the development of specific Nampt inhibitors for treatment of Nampt-associated disorders. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10189872-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10233207-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108697722-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011135332-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323058-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012024478-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11414407-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012024478-A2 |
| priorityDate |
2006-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |