| abstract |
The present invention provides agents for inhibiting the metastasis of cancer cells wherein the agent inhibits the biological activity of hCAP18/LL-37. In a preferred embodiment, the agent alters the transcription, translation and/o binding properties of hCAP18/LL-37. Preferably, the agent is selected from th group consisting of short interfering RNA (siRNA) molecules, antisens oligonucleotides and compounds with binding affmity for hCAP18/LL-37 or it receptor(s). The invention further provides methods for inhibiting the metastasis of cancer cells in a patient, as well as methods and kits for diagnosing cancer. |