| abstract |
The present invention relates to 17-oxymacbecin analogues according to the formula (IA) or (IB) below, or a pharmaceutically acceptable salt thereof, wherein: R1 represents H, OH or OCH3; R2 represents H or CH3 R3 represents H or CONH2 R4 and R5 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R6 represents H or OH; and R7 represents H or CH3. that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies. |