| abstract |
Compounds of formula (I) and the pharmaceutically acceptable salts or solvates thereof, including any stereoisomer or mixture of stereoisomers, in which R1, R2, R3 and R4 are radicals selected independently from the group consisting of H, Cl, F, Br, CF3, (C1-C4)alkyl, (C1-C4)alkoxyl and nitro; R5, R6, R7 and R8 are radicals selected independently from the group consisting of H and (C1-C6)alkoxyl; n is an integer from 3 to 5; r is an integer from 2 to 5; s is an integer from 1 to 5 and X is a biradical selected from CO and CH2. They behave as acetylcholinesterase inhibitors with two bonding sites and are useful as active principles against Alzheimer's disease. |