| abstract |
The present invention relates to a system for targeted active substance delivery for administering a pharmacologically active substance to the central nervous system of a mammal across the blood-brain barrier, where the system for targeted drug delivery comprises nanoparticles of PoIy(DL-lactide) and/or PoIy (DL-lactide-co-glycolide, and at least one pharmacologically active substance which is absorbed in the nanoparticles, is adsorbed thereon or is incorporated therein, and either comprises TPGS or includes a coating of the surface-active substance Pluronic 188, which is deposited on the nanoparticles loaded with active substance, and to methods for producing the system for targeted active substance delivery and to the use of the system for targeted active substance delivery for the treatment of a disease or an impairment of the central nervous system. |