http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007105253-A8
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9418dc5e42e1f620548228272df86404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4836457073b330100207b3321780bf3f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D503-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D505-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D505-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D503-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-06 |
| filingDate | 2007-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b7fe1cfcf4c2d02a85464565f4737b7 |
| publicationDate | 2008-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2007105253-A8 |
| titleOfInvention | PREPARATION OF (1-OXA- OR l-THIA-)3- CEPHEM DERIVATIVES |
| abstract | There is described a process for the preparation of carboxy-protected 7β-amino-7α-methoxy-(l-oxa- or l-thia-)3-(l-substituted-lH-tetrazol-5-yl)thiomethyl-3- cephem-4-carboxylic acid. Said process comprises (a) reacting a carboxy- protected 7-amino-3-chloromethyl-(l-oxa- or 1-thia-) 3-cephem-4-carboxylate with an alkyl- or aryl-sulfenyl chloride; (b) reacting the corresponding 7-alkyl- or aryl-thioimino derivative with a l-(alkyl- o ω-hydroxyalkyl-)lH-tetrazol-5- ylthiol; and (c) reacting the corresponding 7-(alkyl- or aryl-)thioimino-3-(l- substituted-lH-tetrazol-5-yl)Momethyl- (1-oxa- or l-thia-)3-cephem with methanol in the presence of triphenylphosphine and aluminum chloride neutralized with a base. The reaction of the obtained carboxy-protected 7β-amino- 7α-methoxy-(1-oxa- or 1 -thia-)3 -(1-substituted- 1H-tetrazol-5 -yl)thiomethyl-3 - cephem-4-carboxylic acid with activated 2-(cyanomethylthio)acetic or 2- (difiuoromethyl thio)acetic acid affords, after final removal of the protecting ester group, cefmetazole and fiomoxef, respectively. The 7-(alkyl- or aryl)thioimino-3- (1-substituted-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa-3-cephem intermediates are new compounds. |
| priorityDate | 2006-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.