| abstract |
The present invention provides nucleic acid constructs comprising a nucleotide sequence encoding an EphA2 antigenic peptide and Listeria comprising such constructs. In particular, the present invention provides Listeria engineered to express a plurality of EphA2 antigenic peptides and immunogenic compositions comprising such Listeria. The invention encompasses, inter alia, the use of the immunogenic compositions for eliciting an immune response against an EphA2-expressing cell, as well as for the treatment, management and/or prevention of a hyperproliferative disorder and/or a disease involving aberrant angiogenesis. |