| abstract |
A novel method for the preparation of stavudine polymorphic form I and form II is described; it's prepared starting from 5'-acetate-2',3'-diacetyl-5-methyluridine. The 5' -acetate-2',3'-diacetyl-5-methyluridine, by reaction with catalytic amounts of sodium methoxide in a C1-C4 alcholic solvent, gives crude stavudine form II. Crude stavudine form II, which doesn't need to be isolated or purified, can be converted into polymorphic form I by slurry at reflux in isopropanol. |