http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007098387-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c76062144c11b90074449b37c25b679 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e93e26fac63a6b05be4c7218a31650ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a5733ba8a6dc39ffacfd824bbb5ca1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de35f25aef466af2b42b3eeb92bb4bdc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-435 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2007-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e12c6ae36f2efadfaf2628c21dc5d08a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a30a78bfa07fef0af3965171ec3b66e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ceeb2d4fb98346c7d3d2a88fa8cd4ee |
| publicationDate | 2007-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2007098387-A2 |
| titleOfInvention | Antihypertensive therapy |
| abstract | A new use of darusentan is provided in preparation of a pharmaceutical composition for lowering blood pressure in a patient exhibiting resistance to a baseline antihypertensive therapy with one or more drugs. The composition comprises darusentan in an amount providing a therapeutically effective daily dose; wherein (a) the composition is orally deliverable and/or (b) the daily dose of darusentan is effective to provide a reduction of at least about 3 mmHg in one or more blood pressure parameters selected from trough sitting systolic, trough sitting diastolic, 24-hour ambulatory systolic, 24-hour ambulatory diastolic, maximum diurnal systolic and maximum diurnal diastolic blood pressures. Further provided is a new use of darusentan in preparation of a pharmaceutical composition for lowering blood pressure in a patient exhibiting resistance to a baseline antihypertensive therapy, wherein the composition is administered adjunctively with at least one diuretic and at least one antihypertensive drug selected from ACE inhibitors, angiotensin II receptor blockers, beta-adrenergic receptor blockers and calcium channel blockers. |
| priorityDate | 2006-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1433.