| abstract |
The present invention relates to self-assembled nanostructures, comprising hydrophobic bioactive peptides and hydrophobic materials, more specifically, to nanostructures, in which conjugates of hydrophobic bioactive peptides (e.g., cell adhesion-inducing peptides, tissue growth factor-derived peptides, cell- permeating peptides, etc.) and hydrophobic materials are self-assembled and which can not only be used for the surface treatment of biomaterials but also be applied directly for tissue regeneration therapy. The inventive nanostructures are formed through the process in which molecules, each having a hydrophilic moiety and a hydrophobic moiety, are self-assembled into a specific shape in an aqueous system. Accordingly, unit nanostructures can contain peptides in an amount much larger than that attainable by other surface treatment methods, and thus the nanostructures can considerably increase interactions with initial cells. Also, because the nanostructures can efficiently attach peptides, which can recognize cells and intracellular differentiation proteins, to the surface of biomaterials, the nanostructures can promote the adhesion, proliferation and differentiation of cells in injured tissue. |