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filingDate 2007-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97ed4ea5047788ca9c066e00432ac3b8
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publicationDate 2007-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2007091109-A1
titleOfInvention Pharmaceutical composition comprising tacrolimus
abstract The present invention relates to a new pharmaceutical composition comprising tacrolimus in a stable amorphous morphological form with one or more pharmaceutically acceptable excipients characterized that the pharmaceutical composition is not in a solid dispersion form. Furthermore the present invention relates to a process for the preparation of said pharmaceutical composition comprising mixing the diluent and the binder; adding to the resultant mixture the solvent of tacrolimus in ethanol; granulating the resultant mixture; drying the granules; regranulating and homogenizing the granules with the outer phase; optionally adding additional excipients and compressing into tablets or filling into capsules.
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