| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a1528bbf19693953f1b0c2a6df14c31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_547e89ab193b3534054eea1c224be920
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10c37fe9b74cb34db5cf942b26dcdd3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f98e77d1aba3a9c2fb565cc42cc7c76f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6b76ac146981a44e5f90f6264c29327 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-712 |
| filingDate |
2007-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8a3f78c06b8c24668637114cd5a363c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01e3009bdabdd15cc38638ff65ae1971
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cad9190057513137bd50ac52c980bcd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_259a29a69c7e6369e828a5004bb438b8 |
| publicationDate |
2007-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007085485-A3 |
| titleOfInvention |
Lna modified phosphorothiolated oligonucleotides |
| abstract |
The current invention provides oligonucleotides which comprise a dinucleotide consisting of a 5' locked nucleic acid (LNA), a phosphorothioate intemucloside linkage bond to a 3' RNA or RNA analogue. The dinucleotide reduces the strength of hybridization of the oligonucleotide to a complementary nucleic acid target. The modification can be used to modulate hybridisation properties in both single stranded oligonucleotides and in double stranded siRNA complexes, particularly in oligonucleotides where the use of LNA results in excessively strong hybridisation properties. |
| priorityDate |
2006-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |