| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e55505cfa2a65469675839ecaa663aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11026a836d3bc3af3d2aa35fec4844a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69b477d52eba336b4ba6291fcccd4a9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a90987ab04148d48ee30b6d06bb12746 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-536
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N31-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2006-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd4d1104cf9a33e91e42437b228d734e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_016337d8968f7a7f59344858e0995b56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac9acce6d7114793af23cec04f4cedf3 |
| publicationDate |
2007-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007081520-A2 |
| titleOfInvention |
Methods for characterizing molecular interactions |
| abstract |
Methods are provided for measuring rate constants for high affinity molecular interactions using an assay format for determining dissociation rates in liquid phase. The invention uses a biosensor that at selected time intervals is contacted with a sample solution to estimate the ratio of bound vs. free ligand. Dissociation rate constants determined according to the methods of the invention more closely mimic in vivo binding constants and avoid diffusional barrier artifacts that accompany measurements performed using solid phase devices. The methods of the invention provide further advantage by not requiring continuous measurements be made on a biosensor instrument thus leaving it available to process other samples. The methods permit accurate determination of dissociation rates of reactions for which dissociation slowly occurs over intervals of hours to days or more. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8647588-B2 |
| priorityDate |
2006-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |