| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_312c24d5d46861fbd5fe0a40c7d98b4e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_676b80da7ac92b84e447a83fb1630ae1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bfab3d2e2b90edf47709890a7abdc881
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ede40e9946082cb25ccfe3d5bc390f67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_268fce792c5a69a65b631688e4d8092c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4947937fb49fdabcf771f3018ea7c504 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-04001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y401-0109 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-644
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6424
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-647
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 |
| filingDate |
2006-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12ce084abf245cfb7247d71fdbc32b1a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e2de75c28b978e7bd4353b2051d377e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3b3908ddcd98398a60e773604e09e0e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c76edc6c82407fa5cf1644698596b587 |
| publicationDate |
2007-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007075976-A3 |
| titleOfInvention |
Method of producing biologically active vitamin k dependent proteins by recombinant methods |
| abstract |
The invention relates to commercially viable methods for producing biologically active vitamin K dependent proteins, particularly Factor IX. Factor IX is produced at a level of at least about 15 mg/L and is at least 25% biologically active. The method relies upon co-expression of one or more of paired basic amino acid converting enzyme (PACE), vitamin K dependent epoxide reductase (VKOR) and vitamin K dependent Ϝ-glutamyl carboxylase (VKGC) at a preferred ratio so that the vitamin K dependent protein is efficiently produced and processed by a recombinant cell. |
| priorityDate |
2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |