| abstract |
A method for increasing the enantiomeric purity of a desired enantiomer of 3- aminopiperidine comprising: providing a composition containing (i?)-3-arninopiperidine and (jS)-3-aminopiperidine; combining the composition with a resolving agent selected from the group consisting of dibenzoyl-D-tartaric acid; di(ortho-tolyl)-D-tartaric acid; 7V-acetyl-D- phenylalanine; mixtures of two or more of dibenzoyl-D-tartaric acid, di(ortho-tolyl)-D- tartaric acid, and iV-acetyl-D-phenylalanine; dibenzoyl-L-tartaric acid; di(ortho-tolyl)-L- tartaric acid; iV-acetyl-L-phenylalanine; and mixtures of two or more of dibenzoyl-L-tartaric acid, di(ortho-tolyl)-L-tartaric acid; and iV-acetyl-L-phenylalanine in a solvent effective to dissolve the racemic 3-aminopiperidine and the resolving agent, and to crystallize the crystalline diastereomeric salt, which is enriched in either the (i?)-3-aminopiperidine diastereomer or the (-S)-3-aminopiperidine diastereomer. |