Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_64c4e89d7fc1d93f7e2c6def09cb075c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e1084bf8b0613fc542ea5208287f544c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba461a508e9864bcdc8f689af05d83bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a56f318a678f1b1dd1dd703e80b3a754 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_35fd573791cb4a7b78c61fc023ba3b34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1b039cc20399ca4e6cff018d59ed0a5 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
filingDate |
2006-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d33f86dd8b2a928ec03a2aa9b1a22a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1083d508fb30dbbc4ed3f3fcc9545c77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d340b41383a2bf791e4c7b039f051009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef80ead47a68905d59b3fc5f15f84d8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb77081bb1bc8978e603e0ab9aef960e |
publicationDate |
2007-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2007072114-A1 |
titleOfInvention |
An improved process for the manufacture of montelukast sodium |
abstract |
An improved process for the manufacture of 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropane acetic acid, sodium salt [montelukast sodium(I)]. It consists of converting a vital intermediate 1-(mercaptomethyl)-cyclopropane acetic acid of formula IX, to a quaternary ammonium salt of formula X, using a suitable base in a suitable solvent at 0°C to 50°C followed by monometalation to provide an intermediate of formula XI and subsequent condensation of XI with 2-[2-[3-(S)-[3-[2-(7-chloro-2-quinolinyl)-ethenyl] phenyl]-3-methanesulphonyloxypropyl] phenyl]-2-propanol at 0 to -50°C to afford 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropane acetic acid as the quaternary ammonium salt which is filtered, purified by crystallization from a suitable solvent and finally treated with a sodium base in a suitable solvent to generate montelukast sodium which is isolated by trituration with an antisolvent. The invention provides a convenient process for preparing montelukast sodium (I) in good yields and purities. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101072896-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009048236-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009111998-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011121091-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7812168-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011500555-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8426599-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101808998-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8188285-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009111998-A3 |
priorityDate |
2005-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |