http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007072100-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c5730ba22da48fbf56e370c6bdf55ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61fced31bcb304b5bfe7394c3796f767 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 |
| filingDate | 2005-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee1f1665c31fd084a7fc3bc676b6d618 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e239d83b93fbbc2d1061176a39837726 |
| publicationDate | 2007-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2007072100-A1 |
| titleOfInvention | Fagonia bruguieri freeze-dried extract as anti-allergic treatment |
| abstract | The whole plant Fagonia bruguieri DC., family Zygophyllaceae was extracted with boiling water and freeze-dried. The LD<SUB>50</SUB> values of the dried extract were 11.5 and 10.75 g/kg i.p. in mice and rats, respectively. Treatment of albino guinea-pigs with the extract in doses of 200 mg/kg (i.v.) or orally antagonized histamine (20 µg/kg i.v.) - and capsaicin (100 µg/kg i.v.) - induced bronchoconstriction without affecting that induced with ACh and 5-HT. The percentage antagonisms were 72 ± 0.9 and 65 ± 4% against histamine and capsaicin, respectively (P < 0.01, N = 10). Exposure of conscious guinea-pigs to histamine aqueous aerosols (10 mg/ml) induced initial graspings and reversible loss of consciousness within 5 minutes. Treatment of the guinea-pigs with the extract in doses of 1.25 g/kg (i.p.) for 20 minutes or orally for 2 hours protected significantly the animals against histamine-induced grasps and loss of consciousness (P < 0.01, N = 11). Fagonia bruguieri freeze-dried aqueous extract and its constituents are claimed to be potential new treatment for allergy. |
| priorityDate | 2005-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 151.