| abstract |
Compounds of of formula (I), are aurora kinase inhibitors:wherein X is -N-, -CH2-N-, -CH2-CH-, or -CH-; R1 is a radical of formula (IA) wherein Z is -CH2-, -NH-, -0-, -S(O)- -S-, -S(O)2 or a divalent monocyclic carbocyclic or heterocyclic radical having 3-7 ring atoms; Alk is an optionally substituted divalent C1-C6 alkylene radical; A is hydrogen or an optionally substituted monocyclic carbocyclic or heterocyclic ring having 5-7 ring atoms; r, s and t are independently 0 or 1, provided that when A is hydrogen then at least one of r and s is 1; R2 is halogen, -CN, -CF3, -OCH3, or cyclopropyl; and R3 is a radical of formula (IB) wherein Q is hydrogen or an optionally substituted phenyl or monocyclic heterocyclic ring with 5 or 6 ring atoms; Z1 is -S-, -S(O)-, -S(O)2-, -O-, -SO2NH-, -NHSO2-, NHC(=O)NH, -NH(C=S)NH-, Or -N(R4)- wherein R4 is hydrogen, C1-C3 alkyl, cycloalkyl, or benzyl; and Alk1 and Alk2 are, independently, optionally substituted divalent C1-C3 alkylene radicals; and m, n and p are independently 0 or 1. |