| abstract |
A method for manufacturing an oral disintegrating preparation, comprising: (a) molding a complex aluminum substrate material with blister molding equipment, forming a plurality of depressions in the said complex aluminum substrate material, the said complex aluminum substrate material comprises an intermediate aluminum layer, a first and second outer layers, the material of the first outer layer differs from the second outer layer, the flexural rigidity of the first outer layer differs the second outer layer by 0-30%; (b) filling a liquid pharmaceuticals into the depressions formed in the step (a); (c) freezing the pharmaceuticals; (d) freeze-drying the pharmaceuticals; (e) attaching a lidding material to the said package material to seal the pharmaceuticals. |