| abstract |
The present invention relates to Dibenzonaphthyridine Derivatives , compositions comprising an ef fective amount of a Dibenzonaphthyridine Derivative and methods for treating or preventing a proliferative disorder, comprising administering to a subj ect in need thereof an ef f ective amount of a Dibenzonaphthyridine Derivative of formula ( I ) : or a pharmaceutically acceptable salt thereof, wherein R1 is -H, -OH, -O-C1,-C6 alkyl, -halo, -C2-C6 alkenyl, -C2-C6 alkynyl, -N(RI8)2, -NH-OR18 or-C(0)N(Rl8)2; R2 is -H, -0-C1-C6 alkyl, -halo, -C2-C6 alkenyl, -C2-C6 alkynyl, -NHR17. -N(RI7)2, -NH-OR18 or -C(O)N(RI8)2, such that when R1 is -OH or -0-C1-C6 alkyl, R2 is hydrogen; R3, R4, R5, R6, R7, R8. R9 and R10 are each independently -H, -halo, -OH, -SH, -N(RI2)2, -NHOR12, -CN, -NO2, -CF3, -OCF3, -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -C3-C8 cycloalkyl, -C3-C8 cycloalkenyl, -phenyl, -benzyl, -(CH2)n-O-C1-C6 alkyl, -0-C2-C6 alkenyl, -0-C2-C6 alkynyl, -O-phenyl, -S-phenyl, -NH-C1-C6 alkyl, -(CH2)n-C(O)-R11, -(CH2)n-O)-R11, -(CH2)n-NHC(O)-R11, -S-C1-C6 alkyl, -S(O)-C1-C6 alkyl, -SO2-C1-C6 alkyl, -SO2NH-C1-C6 alkyl, -SO2NH-C2-C6 alkenyl, -SO2NH-C2-C6 alkynyl, -Y-(CH2)K-M- CH(R14)R15, -Y-(CH2)g-R16, -Y-(CH2)k-M-(CH2)p-R16, -Y-(CH2)k-(W)a-(CH2)q-Z, -Y-(CH2)P- (Z)_-(CH2)q-Z, or such that R3, R4, R5, R6, R7, R8, R9 and R10 are not simultaneously hydrogen. |