| abstract |
The present invention provides compounds having the structure of Formula (I), wherein R1 is optionally substituted lower alkyl, optionally substituted cycloaikyl, or optionally substituted aryl; R2 is hydrogen, carboxyalkyl, optionally substituted lower alkyl, optionally substituted cycloaikyl, or optionally substituted aryl; R3 is optionally substituted aryl or optionally substituted heteroaryl; R4, R5, and R6 are independently hydrogen or optionally substituted lower alkyl with the proviso that R5 and R6 are not both lower alkyl; and A is 5 or 6 membered monocyclic cycloalkylene or monocyclic arylene ring, useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidemias and metabolic syndrome. The invention also relates to pharmaceutical compositions containing them. |