http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007066069-A3

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filingDate 2006-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_035130aaa0a29d2fb3e5ce1ce502fd74
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publicationDate 2007-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2007066069-A3
titleOfInvention Process for the preparation of poly(alkoxylated) oligonucleotides
abstract A process for the preparation of a poly(alkoxylated) oligonucleotide is provided. The process comprises reacting an oligonucleotide which has been purified by ultrafiltration with a poly(alkoxide) thereby to form a poly(alkoxylated) oligonucleotide. The poly(alkoxyalted) oligonucleotide may be separated from non-poly(alkoxyalted) oligonucleotide by ultrafiltration under denaturing conditions, such as the presence of organic solvents, for example, ethanol; the presence of urea; the addition of chaotropic salts, for example perchlorate and guanidinium salts; the presence of formamide; and the application of heat, for example a temperature of up to about 70°C.
priorityDate 2005-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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