| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1cce8faefafac6cee21571ac1e9bae0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59053460cb1a32cc579f1d17478ddf0f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff9798cff8e8c5b904f26c49a706cb6d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9414eb8baa5e3ff1d70c9b21b4cdb1ba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-10043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-21 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
2006-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_867637c099dd9ab5259a798b7d6e81d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_270780b3f83c6e6ca7e59c9159f9da8b |
| publicationDate |
2007-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007054788-A1 |
| titleOfInvention |
Expression system incorporating a capsid promotor sequence as an enhancer of a cytomegalovirus promotor |
| abstract |
The invention provides a method for enhancing expression of a transgene in a host cell, which includes the steps of inserting a capsid promoter element (Pcap), or a sequence comprising the reverse complement of the capsid promoter element (PcapR), into a mammalian expression cassette upstream (5') of a cytomegalovirus immediate/early enhancer/ promoter region (Pcmv); inserting the transgene into the expression cassette downstream (3') of the cytomegalovirus immediate/early enhancer/ promoter region; inserting a vector containing the expression cassette into the host organism; and causing expression of the transgene. The capsid promoter element (Pcap) is typically from a circovirus, parvovirus or anellovirus. The transgene is typically expressed at a higher level than when expressed by a vector containing the expression cassette without the transcriptional control element. An expression cassette, vector, DNA vaccine, pharmaceutical composition and method of treatment are also claimed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110628765-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110628765-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AP-2580-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102716476-A |
| priorityDate |
2005-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |