| abstract |
The present invention is concerned with aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives of formula (I) wherein R1 is hydrogen, lower alkyl or aryl; R2 is lower alkyl; R3 is hydrogen or halogen; R4/R5 is independently from each other hydrogen, lower alkyl, lower alkinyl, -(CH2)n-cycloalkyl, -(CH2)n-heteroaryl, -(CH2)n-heterocyclyl or -(CH2)n-OH; n is 0, 1, 2 or 3; and with their pharmaceutically acceptable acid addition salts. It has been found that this class of compounds show high affinity and selectivity for GABA α 5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease. |