| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11d05e40924c78e685d633fda269401b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7267e0bdb3678bdb229840cea38a8ff5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc267340cb37eadab3e84a755af683b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10d7b1a4517088ba4cd6803700354654 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-325
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-325 |
| filingDate |
2006-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5e43c5fd83a997e892af1c11e359c96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d64e8fe1c1ed78caba52e9353f5416b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8012de106c6f978a1f864eb1dd812869 |
| publicationDate |
2007-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007041294-A3 |
| titleOfInvention |
Methods for sensitizing cancer cells to inhibitors |
| abstract |
The present invention is based on the discovery that inactivation of the heat shock response in cancer cells significantly enhances their sensitivity to proteasome and Hsp90 inhibitors. The inventors have discovered novel compounds which exhibit low toxicity, inhibit the heat shock protein response and sensitize cancer cells to anti- cancer therapies. In general, the heat shock protein inhibitors of the present invention share a common structure, namely a 2H-benzo[a]quinolizine tricyclic ring. Also encompassed are methods for a high throughput screen to identify heat shock inhibitors that sensitize cancer cells to anti-cancer therapies. |
| priorityDate |
2005-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |