| abstract |
The invention provides N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-3-methyl-5-isoxazolecarboxamide Formula (I): or a salt thereof, such as the compound or a pharmaceutically acceptable salt thereof. The invention also provides the use of the compound or salt as an inhibitor of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of an inflammatory and/or allergic disease, especially an inflammatory and/or allergic skin disease such as atopic dermatitis, in a mammal such as a human. External topical administration, e.g. topical administration to the skin, of the compound or salt is preferred, and external-topical pharmaceutical compositions are provided |