| abstract |
The invention relates to a novel method of obtaining amorphous calcium atorvastatin from N-phenyl-2-[1-phenyl-2-(4-fluorophenyl)-2-oxo]ethyl-4-methyl-3-oxo-pentanamide (II) and (3R,5R)-7-amino-3,5-(O- isopropylidene)dihydroxy-heptanoate of terc-butyl (III), by reacting same with toluene reflux in the presence of an acid catalyst, using a series of synthesis, isolation and hydrolysis steps, after which the crude amorphous atorvastatin obtained is purified, isolated and dried, said steps being performed under very smooth reaction conditions using very short reaction times, moderate temperatures and minimal amounts of reagents, thereby producing a high-quality product. |