| abstract |
An oral tablet formulation of moxifloxacin or its salts and/or hydrates, comprises at least one film-forming material used for coating the intermediate particles. Said film-forming material may be one or more of hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, methylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, sodium carboxymethycellulose, polyacrylic resins, polyethylene glycol, polyvinylpyrrolidone vinylacetate copolymer, PVA-PEG graft copolymer, carbopol, gelatin, poloxamer, polyvinylpyrrolidone. Preparation of said formulation comprises: mixing or granulating moxifloxacin blended with excipients, coating the intermediate granular with the film- forming material, then compressing the mixture. The invented tablet formulation has a prolonged shelf life and rapid dissolution. |