| abstract |
The present invention provides analogs of formula (I) of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF. The compounds (II) are used to treat diabetes, inflammatory and autoimmune conditions. wherein R1 is hydrogen or a group having the formula -C(=O)R3, wherein R is lower alkyl, and R2 is selected from the group consisting of. |