Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75f2a579a509cf6ef981af4ec0a868c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb3b874314f72fd14b113d668789923c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2fc8c4f23758df7ed658973e2a913e38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba596f6a55175fe225331a7b8a5b5db3 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-30 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate |
2006-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80631180c49f2ae58940a5384ea49b16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bd41d0df7e2453bfc12d7a04ca9e764 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af7e74670603d0a29e1012935ddfac70 |
publicationDate |
2007-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2007022635-A2 |
titleOfInvention |
Methods of attenuating prostate tumor growth by insulin-like growth factor binding protein-3 (igfbp-3) |
abstract |
Insulin-like Growth Factor Binding Protein - 3 (IGFBP-3) inhibits cell growth and promotes apoptosis by sequestering free Insulin-like Growth Factor (IGF), and also demonstrates IGF-independent, pro-apoptotic, anti-proliferative effects on prostate cancer cells. Prostate tumor size was significantly attenuated in transgenic mice over-expressing IGFBP-3 compared with wild-type mice. In addition, a marked reduction in late-stage tumor growth was apparent in transgenic mice over expressing mutant-IGFBP-3 indicating that the IGF-independent effects of IGFBP-3 are related to inhibiting tumor progression. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008019491-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2763687-A4 |
priorityDate |
2005-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |