http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007019540-A3

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filingDate 2006-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2007-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2007019540-A3
titleOfInvention Controlled release alpha-lipoic acid formulation with an inositol compound
abstract A biphasic formulation of an inositol compound and lipoic acid for oral administration is disclosed. The lipoic acid and the inositol compound are combined with excipient materials in such a way that those materials provide for an immediate release of a first portion of the active ingredients from the formulation followed by a gradual release of any remaining active ingredients in a manner which makes it possible to (1) quickly obtain a therapeutic level of the active ingredients; and (2) substantially increase the period of time over which therapeutic levels of the active ingredients are maintained relative to a quick release formulation. These features make it possible to use the formulation to reduce serum glucose levels and maintain those reduced glucose levels over time to treat diabetic polyneuropathy and thereby obtaining a range of desired therapeutic results.
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